Tumor cells have a high metabolic rate, and hence this compound is also metabolized by tumor cells.įDG is metabolized to FDG-6-phosphate which cannot be further metabolized by tumor cells, and hence it accumulates and concentrates in tumor cells. This accumulation is detected and quantified. Uptake of this compound followed by further breakdown occurs in the cells. More recently PET-MRI scanners have become available although their use remains limited and they are generally only found in the larger academic centers, often in a research setting.Ī radiolabelled biological compound such as F-18 fluorodeoxyglucose (FDG) is injected intravenously.
This is in contrast to scintigraphy, which yields planar data which can only be used to create a two-dimensional image.Īlthough the physiologic information afforded by PET and SPECT imaging is invaluable, the quality of obtained data is poor/noisy and limits imaging spatial resolution. For this reason, PET and SPECT scans are often combined with CT imaging, allowing correlation between functional and anatomical imaging (" hybrid imaging"). It involves the intravenous injection of a positron-emitting radiopharmaceutical, waiting to allow for systemic distribution, and then scanning for detection and quantification of patterns of radiopharmaceutical accumulation in the body.Īs with SPECT imaging, PET scan data can be reconstructed and displayed as a three-dimensional image. Positron emission tomography ( PET) is a modern non-invasive imaging technique for quantification of radioactivity in vivo.
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